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Topical glycerol monooleate/propylene glycol formulations enhance 5-aminolevulinic acid in vitro skin delivery and in vivo protophorphyrin IX accumulation in hairless mouse skin

✍ Scribed by Regilene Steluti; Fernanda Scarmato De Rosa; John Collett; Antônio Cláudio Tedesco; Maria Vitória Lopes Badra Bentley

Book ID
116437387
Publisher
Elsevier Science
Year
2005
Tongue
French
Weight
181 KB
Volume
60
Category
Article
ISSN
0939-6411

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In vitro percutaneous absorption and in
In vitro percutaneous absorption and in vivo protoporphyrin IX accumulation in skin and tumors after topical 5-aminolevulinic acid application with enhancement using an erbium:YAG laser
✍ Shing-Chuan Shen; Woan-Ruoh Lee; Yi-Ping Fang; Chung-Hong Hu; Jia-You Fang 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 250 KB

5-Aminolevulinic acid (ALA) is used as a precursor of protoporphyrin IX (PpIX) for photodynamic therapy (PDT) of superficial skin cancers and subcutaneous metastases of internal malignancies. The permeability of ALA across intact skin is always low, making it difficult to achieve the desired therape