The effects of topical betamethasone-17-valerate on collagen propeptide levels, collagen mRNA level, lysyl oxidase mRNA and matrix metalloproteinase (MMP)-1 and MMP-2 mRNA levels were studied in human skin. Three days' treatment of healthy skin with topical betamethasone caused a 70-80% decrease in
โฆ LIBER โฆ
Topical glucocorticoid decreases both collagen synthesis and corresponding mRNA level in human skin in vivo
โ Scribed by HAAPASAARI, K
- Book ID
- 122995932
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 247 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0926-9959
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## Background: Glucocorticoids have been shown to downregulate collagen synthesis in human skin in vivo, thereby contributing to skin atrophy. ## Objectives: To compare the effects of continuous and intermittent use of topical hydrocortisone on skin collagen synthesis and, furthermore, to elucida