✦ LIBER ✦

Topical Antiinflammatory Activity of Two Pimarane Diterpenes from Kaempferia pulchra

✍ Scribed by Tuanta Sematong; Vichai Reutrakul; Patoomratana Tuchinda; Per Claeson; Ubonwan Pongprayoon; Nilufar Nahar

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 153 KB
Volume: 10
Category: Article
ISSN: 0951-418X
DOI: 10.1002/(sici)1099-1573(199609)10:6<534::aid-ptr890>3.0.co;2-c

No coin nor oath required. For personal study only.

✦ Synopsis

l k o diterpenes, 2a-acetoxysandraracopimaradien-1 a-01 (1) and sandaracopimaradien-la,2a-diol(2) isolated from Kolempferia pulchra Ridl. (Zingiberaceae), have been assayed for topical antiinflammatory activity in the model of 12-0-tetradecanoylphorbol-13-acetate-induced ear aedema in rats. Both substances were found active and the ID,-values were estimated to 330 and 50 &ear, respectively. The ID,-value of the reference drug diclofenac was calculated to 90 pglear.