Tooth Enamel Defects in Mice with a Deletion at theArhgap6/AmelXLocus

Mice with a deletion in the first intron

Mice with a deletion in the first intron of the Col1a1 gene develop dissection and rupture of aorta in the absence of aneurysms: High-resolution magnetic resonance imaging, at 4.7 T, of the aorta and cerebral arteries

✍ J. Marjamaa; R. Tulamo; U. Abo-Ramadan; H. Hakovirta; J. Frösen; O. Rahkonen; M. 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 655 KB

## Abstract Deletion of the majority of the first intron of the __Col1a1__ gene in mice leads to decreased type I collagen synthesis and content in the aortic wall. In 54% of cases, mice homozygous for the Col1a1 mutation die of thoracic hemorrhage by the age of 18 months. It is unknown whether the