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Tonic Inhibition of G Protein-Coupled Receptor Kinase 2 of Endothelial Protein Kinase B/Endothelial Nitric-Oxide Synthase Signaling

Book ID: 125454423
Publisher: American Society for Pharmacology and Experimental Therapeutics
Year: 2014
Tongue: English
Weight: 57 KB
Volume: 349
Category: Article
ISSN: 0022-3565
DOI: 10.1124/jpet.114.0514hi

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## Abstract The process of regulation of NOS after production of nitric oxide is not yet delineated. Protein kinase G may exert a feedback regulation of this enzyme. We used diaminofluorescein assays to detect changes in basal nitric oxide production caused by modulators of protein kinase G activit