Tomographic measurement of cerebral blood flow by the68Ga-labelled-microsphere and continuous-C15O2-inhalation methods
✍ Scribed by M. Steinling; J. C. Baron; B. Maziere; P. Lasjaunias; C. Loc'h; E. A. Cabanis; B. Guillon
- Publisher
- Springer
- Year
- 1985
- Tongue
- English
- Weight
- 359 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0340-6997
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✦ Synopsis
The measurement of cerebral blood flow (CBF) by continuous C~502 inhalation has only been validated previously by indirect experimental protocols. In the present study using baboons, these measurements were compared directly with those obtained by injection of 68Galabelled serum-albumin microspheres in the left cardiac ventricle. Using a modified labelling technique, no elution of 68 Ga occurred in vivo. Both methods provided similar regional CBF values, which could be described by a significant linear correlation (CBFco ~ = 0.82 CBFmi .... ph .... n t-5.7; P < 0.001). The validity of the labelled-microsphere-injection method was verified. The feasibility of stable in vivo labelling of 6SGa to serum-albumin microspheres provides a reference method for organ blood-flow measurements using positron-emission tomography.