## and the CAPPS Investigators Low serum sodium concentration is an independent predictor of mortality in patients with cirrhosis, but its prevalence and clinical significance is unclear. To evaluate prospectively the prevalence of low serum sodium concentration and the association between serum s
Tolvaptan and hyponatremia in a patient with cirrhosis
β Scribed by Thomas D. Boyer
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 705 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0270-9139
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In advanced cirrhosis there is a reduction in the brain concentration of many organic osmolytes, particularly myo-inositol (MI). Hyponatremia could theoretically aggravate these changes as a result of hypo-osmolality of the extracellular fluid. The aim of this study was to determine the effects of h
Hyponatremia is a frequent complication of advanced cirrhosis related to an impairment in the renal capacity to eliminate solute-free water that causes a retention of water that is disproportionate to the retention of sodium, thus causing a reduction in serum sodium concentration and hypo-osmolality
We read with interest the study by Sola `et al., 1 who found that 39 patients (67%) had a very alarming decrease in their serum sodium levels ! 5 mEq/L during terlipressin treatment for acute variceal bleeding (AVB). We, however, feel that some of their observations may require a closer look by the