## Abstract According to the current model, naive B cell activation is dependent on the sequential integration of two signals: B cell receptor (BCR) cross‐linking by antigen, followed by cognate interaction with helper T cells through an immunological synapse. Using an improved method to purify hum
✦ LIBER ✦
Toll-like receptor engagement stimulates anti-snRNP autoreactive B cells for activation
✍ Scribed by Chuanlin Ding; Li Wang; Hayma AL-Ghawi; Jose Marroquin; Mark Mamula; Jun Yan
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 499 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0014-2980
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## Abstract ## Objective Toll‐like receptors (TLRs) are pattern‐associated receptors in innate immunity that may be involved in the recognition of self antigens and the production of pathogenic autoantibodies. This study was undertaken to examine the expression and function of various TLRs in subp