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Toll-like receptor 2–mediated innate immune response in human nonparenchymal liver cells toward adeno-associated viral vectors

✍ Scribed by Marianna Hösel; Mathias Broxtermann; Hanna Janicki; Knud Esser; Silke Arzberger; Pia Hartmann; Sonja Gillen; Jörg Kleeff; Dirk Stabenow; Margarete Odenthal; Percy Knolle; Michael Hallek; Ulrike Protzer; Hildegard Büning

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 736 KB
Volume: 55
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.24625

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Hepatitis B virus suppresses toll-like receptor–mediated innate immune responses in murine parenchymal and nonparenchymal liver cells

✍ Jun Wu; Zhongji Meng; Min Jiang; Rongjuan Pei; Martin Trippler; Ruth Broering; A 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 839 KB

We have previously shown that Toll-like receptor (TLR)-activated murine nonparenchymal liver cells [(NPC); Kupffer cells (KC), liver sinusoidal endothelial cells (LSEC)] can suppress hepatitis B virus (HBV) replication. Therefore, the aim of this study was to investigate whether HBV has the ability