𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Tolerance to vascularized organ allografts in large-animal models

✍ Scribed by Tatsuo Kawai; David H Sachs; A Benedict Cosimi

Book ID
104358989
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
73 KB
Volume
11
Category
Article
ISSN
0952-7915

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✦ Synopsis

Although studies of tolerance induction in large animals remain limited compared with murine studies, a number of encouraging observations have been recently reported -especially in nonhuman primate models. The development of antibodies or proteins binding to costimulatory molecules and of an immunotoxin that is active on T cells have been particularly important advances leading to expanded opportunities for extending strategies for tolerance induction to large animals.

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## Abstract De novo generation of axially vascularized tissue with clinically relevant dimensions in a large animal model and implementation of clinically established imaging modalities for in vivo evaluation of vascularization. To be used for reconstruction of tissue defects, engineered grafts nee