Tolerance to the effects of Δ9-THC on shuttle-box performance and body temperature
✍ Scribed by M. Ten Ham
- Book ID
- 113217237
- Publisher
- Elsevier Science
- Year
- 1977
- Tongue
- English
- Weight
- 265 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0091-3057
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Rats trained in conditioned avoidance responding (CAR) after injections of either 7.5 mg/kg zJP-THC (tetrahydroeannabinol) or 15 mg/kg 3S-THC, showed no transfer when tested in the non-drugged state. Furthermore, these doses of the isomeric tetrahydrocannabinols exerted a disruptive effect on previo
The onset and duration of tolerance to three effects of A9-tetrahydrocannabinol (A9-THC) given orally to mice were compared. The effects of A9-THC studied were: hypothermia, the depression of intestinal motility and the effect on spontaneous locomotor activity. When mice were dosed and tested at 24
The development of tolerance to delat9-tetrahydrocannabinol (delta9-THC) was examined. Rats with permanently indwelling intravenous catheters were injected daily with delta9-THC, 2 mg/kg, for up to 10 days and on each day subjective behaviour and body weight of each rat were noted. Tolerance appeare