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Tolerance to self-administration of cocaine in rats: time course and dose-response determination using a multi-dose method

โœ Scribed by Emmett-Oglesby, M.W.; Peltier, R.L.; Depoortere, R.Y.; Pickering, C.L.; Hooper, M.L.; Gong, Y.H.; Lane, J.D.

Book ID
120510604
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
1017 KB
Volume
32
Category
Article
ISSN
0376-8716

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Self-administration of cocaine on a prog
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โœ David C. S. Roberts; Elliot A. Loh; Gary Vickers ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› Springer ๐ŸŒ English โš– 414 KB

Intravenous cocaine self-administration behavior in rats was investigated using a progressive ratio (PR) schedule of reinforcement. The first response on the lever each day produced a drug infusion, whereupon the requirements of the schedule escalated with each reinforcement until the behavior extin