Tolerance induction to a hapten protein conjugate in vivo: Are suppressor T cells involved
โ Scribed by R. Huchet; Marc Feldmann
- Book ID
- 102160635
- Publisher
- John Wiley and Sons
- Year
- 1974
- Tongue
- English
- Weight
- 474 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0014-2980
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A MAb (B16G) which recognizes a constant epitope on TsC and their soluble factors in DBA/2 mice has been described previously. In this study, we show that when this MAb is covalently linked to the photoactivable molecule Hp, and injected i.v. into P815 tumor-bearing mice which were subsequently expo
## Abstract ## Background Host immune responses to foreign gene products have been shown to lead to the elimination of genetically modified cells, and are a major barrier to successful therapeutic gene therapy. We have shown that immunological tolerance to retrovirally transduced cell surface prot