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Tolerance and Dependence Evoked by an Endogenous Opiate Peptide

✍ Scribed by Arthur Lampert, Marshall Nirenberg and Werner A. Klee

Book ID
123653864
Publisher
National Academy of Sciences
Year
1976
Tongue
English
Weight
545 KB
Volume
73
Category
Article
ISSN
0027-8424

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Functional MRI (fMRI) was employed to determine whether repeated heroin self-administration (SA) produces tolerance or sensitization in the brain of heroin-SA rats. Twelve rats were evenly divided into saline and heroin (0.06 mg/kg, 4 hr/day) SA groups. There was a progressive increase in drug-SA be