Tolerability and efficacy of switching from oral selegiline to Zydis selegiline in patients with Parkinson’s disease
✍ Scribed by William G. Ondo; Christine Hunter; Stuart H. Isaacson; Dee E. Silver; R. Malcolm Stewart; James W. Tetrud; Anthony Davidson
- Book ID
- 116820860
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 101 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1353-8020
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## Abstract Tolcapone is a potent, reversible catechol‐O‐methyltransferase (COMT) inhibitor with both peripheral and central activity. It has been demonstrated to improve motor function and allow levodopa dose reductions in Parkinson's disease (PD) patients who are experiencing either a stable resp
Zydis selegiline dissolves on contact with saliva and undergoes pregastric absorption. This minimizes first-pass metabolism and provides high plasma concentrations of selegiline. In this study, the efficacy and safety of Zydis selegiline was assessed in Parkinson's disease (PD) patients who were exp