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Tobacco Mosaic Virus as a Carrier for Small Molecules. II. Cooperative affinity labeling of membrane vesicles with a TMV angiotensin conjugate. Preliminary communication

✍ Scribed by Verena M. Kriwaczek; Jean-Claude Bonnafous; Martin Müller; Robert Schwyzer

Publisher: John Wiley and Sons
Year: 1978
Tongue: German
Weight: 339 KB
Volume: 61
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.19780610406

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✦ Synopsis

Abstract

A (3‐mercapto‐1‐succinyl)‐TMV ϵ‐maleimidohexanoyl‐[1‐asparagine, 5‐valine]‐angiotensin II conjugate was prepared and used for cooperative affinity labeling of bovine adrenal cortex cell membrane vesicles containing angiotensin‐binding sites. The labeling was demonstrated by electron microscopy and by CsCl and sucrose density gradient centrifugation Preliminary evidence for specific binding and for the postulated cooperative affinity interaction is produced.

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Tobacco Mosaic Virus as a Carrier for Sm

Tobacco Mosaic Virus as a Carrier for Small Molecules I. The preparation and characterization of a TMV/α-melanotropin conjugate

✍ Verena M. Kriwaczek; Alex N. Eberle; Martin Müller; Robert Schwyzer 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 German ⚖ 610 KB

## Abstract The use of tobacco mosaic virus (TMV) covalently loaded with hormones or other small molecules for various purposes including receptor detection and isolation is proposed. The basic principle is that of __cooperative affinity interactions__ involving (large) numbers of artificially intr