✦ LIBER ✦

To SIR with Polycomb: linking silencing mechanisms

✍ Scribed by Vivek S. Chopra; Rakesh K. Mishra

Book ID: 101706867
Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 55 KB
Volume: 27
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.20191

No coin nor oath required. For personal study only.

✦ Synopsis

Yeast SIR2, the most evolutionarily conserved deacetylase, plays an essential role in epigenetic silencing at the silent mating type loci and telomeres. SIR2 has been implicated in chromatin silencing and lifespan determination in several organisms. Discovery that Drosophila SIR2 is also involved in epigenetic silencing mediated by the Polycomb group proteins and is physically associated with a complex containing the E(Z) histone methyltransferase (1) has wide implications. These findings suggest possible link of Polycomb system to diverse cellular processes including senescence. BioEssays 27: 119-121, 2005.

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