TNF-α gene polymorphism does not affect the clinical and radiological outcome of rheumatoid arthritis

Polymorphism at position −308 of the tum

Polymorphism at position −308 of the tumor necrosis factor α gene influences outcome of infliximab therapy in rheumatoid arthritis

✍ Benedicte Mugnier; Nathalie Balandraud; Albert Darque; Chantal Roudier; Jean Rou 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 62 KB 👁 1 views

## Abstract ## Objective To test whether the G‐to‐A polymorphism at position −308 in the promoter of the tumor necrosis factor α (TNFα) gene influences response to infliximab therapy in patients with rheumatoid arthritis (RA). ## Methods We genotyped 59 RA patients by polymerase chain reaction a