## Abstract Background p21 (WAF1/CIP1) is a downstream protein from p53 and can arrest the cell cycle at the G1/S phase in response to signal from p53. The most frequently seen polymorphic site is at codon 31, where a base change from AGC to AGA causes an amino acid change from serine to arginine.
✦ LIBER ✦
TNF-α gene polymorphism: Clinical and biological implications
✍ Scribed by Ali H. Hajeer; Ian V. Hutchinson
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 173 KB
- Volume
- 50
- Category
- Article
- ISSN
- 1059-910X
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## Communicated by Michael Dean Alzheimer disease (AD), vascular dementia, and stroke are all associated with inflammation though their respective initiating factors differ. Recently a polymorphism in the proinflammatory cytokine tumor necrosis factor (TNF), in association with apolipoprotein E (A