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TNF-mediated IL6 gene expression and cytotoxicity are co-inducible in TNF-resistant L929 cells

✍ Scribed by Veronique Vandevoorde; Guy Haegeman; Walter Fiers


Book ID
115926139
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
580 KB
Volume
302
Category
Article
ISSN
0014-5793

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We have shown that the loss of p53 function contributed to resistance of tumor cells to TNF-induced cytotoxicity. In the present study, we evaluated the effect of wild-type p53 (wt-p53) expression on TNF sensitivity, by introducing wt-p53 into MCF7/Adr cells in which p53 was deleted, via a recombina