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TNF-mediated cytotoxicity and resistance in human prostate cancer cell lines

✍ Scribed by Nakajima, Yosuke; DelliPizzi, Ann Marie; Mallouh, Camille; Ferreri, Nicholas R.

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 646 KB
Volume: 29
Category: Article
ISSN: 0270-4137
DOI: 10.1002/(sici)1097-0045(199611)29:5<296::aid-pros4>3.0.co;2-8

No coin nor oath required. For personal study only.

✦ Synopsis

BACKGROUND.

The contribution of TNF receptor (TNF-R) expression was investigated with respect to TNF sensitivity or insensitivity for androgen-dependent and androgenindependent human prostate cancer (PCA) cell lines, respectively.

METHODS.

Flow cytometric analyses using monoclonal antibodies against the 55-kDa receptor (TNF-Rl) and the 75-kDa receptor (TNF-R2) indicated that both receptors were expressed on all three cell lines.

RESULTS.

Moreover, expression of TNF-R1 was greater than expression of TNF-R2 in these PCA cells, AU three PCA cell lines produced IL-6. However, IL-6 production was enhanced when TNF-insensitive JCA-1 and PC-3 cells, but not TNF-sensitive LNCaP cells, were treated with rTNF M).

CONCLUSIONS. These data suggest that the lack of an antiproliferative effect of rTNF on the androgen-independent PCA cell lines PC-3 and JCA-1 is not due to the failure of these cells to express TNF-R, but may be related to the differences in TNF-mediated IL-6 expression by these PCA cell lines.

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