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TNF autovaccination induces self anti-TNF antibodies and inhibits metastasis in a murine melanoma model

โœ Scribed by Waterston, A M; Salway, F; Andreakos, E; Butler, D M; Feldmann, M; Coombes, R C


Book ID
109997980
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
139 KB
Volume
90
Category
Article
ISSN
0007-0920

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Anti-tumor effect of recombinant murine
โœ M. Scheringa; A. Keizer; J. Jeekel; R. L. Marquet ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 508 KB

Anti-tumor effects of TNF in animal models are well documented. Therapeutic use of TNF, however, is hampered by its toxicity. In rats a single intravenous (i.v.) injection of 40 pg/kg is lethal. When given by continuous i.v. infusion, much higher doses are well tolerated. To compare the therapeutic