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TNF-alpha induced chondrocyte apoptosis in NF-κB suppression is augmented by inhibition of p38 mitogen-activated protein kinase or phosphatidylinositol 3-kinase

✍ Scribed by H Kim

Book ID
120708120
Publisher
BioMed Central
Year
2003
Tongue
English
Weight
554 KB
Volume
5
Category
Article
ISSN
1478-6354

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## Abstract Cytokine‐induced expression of inducible nitric oxide synthase (iNOS) and concomitant production of nitric oxide (NO) involve activation of mitogen‐activated protein (MAP) kinases and are in most cases mediated by the transcription factor NF‐κB. We investigated the role of p38 MAP kinas