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TNA Synthesis by DNA Polymerases

✍ Scribed by Chaput, John C.; Szostak, Jack W.


Book ID
127290893
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
54 KB
Volume
125
Category
Article
ISSN
0002-7863

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## Abstract DNA interstrand crosslinks (ICLs) are induced by a number of bifunctional antitumor drugs such as cisplatin, mitomycin C, or the nitrogen mustards as well as endogenous agents formed by lipid peroxidation. The repair of ICLs requires the coordinated interplay of a number of genome maint