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Tn4001: A gentamicin and kanamycin resistance transposon in Staphylococcus aureus

✍ Scribed by Lyon, Bruce R. ;May, John W. ;Skurray, Ronald A.

Publisher
Springer
Year
1984
Tongue
English
Weight
439 KB
Volume
193
Category
Article
ISSN
0026-8925

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✦ Synopsis

We describe a 4.5 kilobase transposon, Tn4001, which mediates resistance to gentamicin, tobramycin and kanamycin in Staphylococcus aureus. Originally detected in plasmid pSK1, Tn4001 was shown to undergo rec-independent transposition to the chromosome from this plasmid and from an inserted derivative of the plasmid pII147. Heteroduplexes between plasmids with and without Tn4001 demonstrated a characteristic stem and loop structure with inverted repeats of approx. 1.3 kilobases.

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