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TMT-induced autonomic and behavioral changes and the neural basis of its processing

โœ Scribed by Markus Fendt; Thomas Endres; Catherine A. Lowry; Raimund Apfelbach; Iain S. McGregor

Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
268 KB
Volume
29
Category
Article
ISSN
0149-7634

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โœฆ Synopsis

One of the main interests in the field of neuroscience is the investigation of the neural basis of fear. During recent years, an increasing number of studies have used trimethylthiazoline (TMT), a component of red fox feces, as a stimulus to induce fear in predator naive rats, mice, and voles. The aim of the present review is to summarize these studies. We present an overview to the autonomic and behavioral changes that are induced by TMT exposure. Then, we summarize the small number of studies that have examined the neural processing of the TMT stimulus. Finally, we compare these studies with those using a natural predator or predator odor to induce fear and discuss the possible use of TMT exposure in rodents as an animal model of unconditioned fear in humans.

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