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TMP-153, a novel ACAT inhibitor, inhibits cholesterol absorption and lowers plasma cholesterol in rats and hamsters

โœ Scribed by Yasuo Sugiyama; Eiichiro Ishikawa; Hiroyuki Odaka; Nanami Miki; Hiroyuki Tawada; Hitoshi Ikeda


Book ID
118324491
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
678 KB
Volume
113
Category
Article
ISSN
0021-9150

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Effect of the ACAT inhibitor CI-976 on p
โœ Brian R. Krause; Richard F. Bousley; Karen A. Kieft; Richard L. Stanfield ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 724 KB

The overall objective of the present study was to determine if the ACAT inhibitor CI-976 can lower plasma cholesterol in hamsters fed zero or low, "human-like" levels of cholesterol. With a purified diet containing zero dietary cholesterol, CI-976 significantly lowered VLDL cholesterol (VLDL-C), but