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TmDOTP5−: A substance for NMR temperature measurements in vivo

✍ Scribed by Chun S. Zuo; John L. Bowers; Kenneth R. Metz; Toshihisa Nosaka; A. Dean Sherry; Melvin E. Clouse

Book ID
102954972
Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
525 KB
Volume
36
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

The chemical shifts of ^31^P and ^1^H in thulium 1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetrakis(methylene phosphonate) (TmDOTP^5−^) are approximately two orders of magnitude more sensitive to temperature than are water proton and ^19^F shifts. In the physiologically relevant pH range, the ^31^P and ^1^H chemical shifts of TmDOTP^5−^ are linear functions of temperature between 25 and 47°C. The results indicate that using TmDOTP^5−^ can provide measurements of temperature in vivo that are significantly more accurate than methods based on water and fluorocarbon chemical shifts.

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