Islet-expressed TLR2 and TLR4 sense inju
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Bernd KrΓΌger; Na Yin; Nan Zhang; Anju Yadav; William Coward; Girdhari Lal; Weipi
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Article
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2010
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John Wiley and Sons
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English
β 513 KB
## Abstract Although islet transplantation is an effective treatment for Type 1 diabetes, primary engraftment failure contributes to suboptimal outcomes. We tested the hypothesis that islet isolation and transplantation activate innate immunity through TLR expressed on islets. Murine islets constit