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TLR4 Mediates Early Graft Failure After Intraportal Islet Transplantation

✍ Scribed by Q. Gao; L. L. Ma; X. Gao; W. Yan; P. Williams; D. P. Yin


Book ID
114805617
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
595 KB
Volume
10
Category
Article
ISSN
1600-6135

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## Abstract Although islet transplantation is an effective treatment for Type 1 diabetes, primary engraftment failure contributes to suboptimal outcomes. We tested the hypothesis that islet isolation and transplantation activate innate immunity through TLR expressed on islets. Murine islets constit