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TLR2 expression and signaling-dependent inflammation impair wound healing in diabetic mice

✍ Scribed by Dasu, Mohan R; Thangappan, Ravi K; Bourgette, Alika; DiPietro, Luisa A; Isseroff, Rivkah; Jialal, Ishwarlal

Book ID
109885460
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
346 KB
Volume
90
Category
Article
ISSN
0023-6837

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## Abstract Wound healing is impaired in elderly patients with diabetes mellitus. We hypothesized that age‐dependent impairment of cutaneous wound healing in __db__/__db__ diabetic mice: (a) would correlate with reduced expression of the transcription factor hypoxia‐inducible factor 1Ξ± (HIF‐1Ξ±) as