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TLC resolution of enantiomers of amino acids and dansyl derivatives using (1R,3R,5R)-2-azabicyclo[3,3,0]octan-3-carboxylic acid as impregnating reagent

✍ Scribed by R. Bhushan; J. Martens; Sabine Wallbaum; Shalini Joshi; Vineeta Parshad

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
110 KB
Volume
11
Category
Article
ISSN
0269-3879

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✦ Synopsis

The enantiomeric resolution of certain amino acids and some of their dansyl derivatives was achieved on thin silica gel plates impregnated with (1R, 3R, 5R)-2-Azabicyclo[3,3,0]octan-3-carboxylic acid, which is an industrial waste material, and a proline analogue non proteinogenic ␣-amino acid. Different combinations of 0.5 M NaCl-MeCN were found to be successful in resolving dansyl-DL-amino acids; addition of methanol was required in some cases. Spots were visualised using a fixed wavelength (254 nm) ultraviolet chamber. Resolution of DL-amino acids was successful in different combinations of MeCN-MeOH-H 2 O and detection was made with ninhydrin (0.2% in acetone).

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