Titin and ryanodine receptor antibodies in myasthenia gravis
β Scribed by G. O. Skeie; J. A. Aarli; N. E. Gilhus
- Book ID
- 109337399
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 440 KB
- Volume
- 113
- Category
- Article
- ISSN
- 0001-6314
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To improve the sensitivity of the radioimmunoassay method for anti-AChR-antibody, large amounts of sera from patients with myasthenia gravis, and higher concentrations of antigens and rabbit anti-human-IgG-antiserum, were used. These procedures enabled measurement of the titre value of over 0.04 pmo
## Abstract Patients with myasthenia gravis can have antibodies against skeletal muscle ryanodine receptor (Ry1), the sarcoplasmic reticulum calciumβrelease channel, which plays a crucial role in excitationβcontraction coupling. We have screened a panel of overlapping Ry1 fusion proteins with Ry1 a