Epidermal growth factor (EGF) causes gender-and development-specific changes in fetal lung surfactant synthesis. We hypothesized that the effects of EGF on development of surfactant synthesis are related to effects on EGF receptor (EGF-R) expression. We prepared sex-specific fetal rabbit lung organ
✦ LIBER ✦
Tissue uptake of EGF receptor antisense oligonucleotides in organ culture of fetal mouse palates and their effects on in vitro palatogenesis
✍ Scribed by Hiroshi Naitoh; Chisato Mori; Naoki Ohyama; Hidekazu Irie; Noriko Nakamura; Yoshihiko Nishimura; Kohei Shiota
- Book ID
- 111300673
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 879 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0914-3505
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## Abstract ## BACKGROUND 2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin (TCDD) is teratogenic in mice, producing cleft palate (CP). TCDD exposure disrupts expression of epidermal growth factor (EGF) receptor, EGF, and transforming growth factor‐α (TGFα) in the palate and affects proliferation and differenti