Tissue-Type Plasminogen Activator Is a Multiligand Cross-β Structure Receptor
✍ Scribed by Onno Kranenburg; Barend Bouma; Loes M.J. Kroon-Batenburg; Arie Reijerkerk; Ya-Ping Wu; Emile E. Voest; Martijn F.B.G. Gebbink
- Book ID
- 114319439
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 301 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0960-9822
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## Abstract ## Objective Regulation of the conversion of plasminogen to plasmin by tissue plasminogen activator (tPA) is critical in the control of fibrin deposition. While several plasminogen activators have been described, soluble plasma cofactors that stimulate fibrinolysis have not been charac
Full-length tissue-type plasminogen activator (t-PA) cDNA served to construct deletion mutants within the N-terminal "heavy" (H)-chain of the t-PA molecule. The H-chain cDNA consists of an array of structural domains homologous to domains present on other plasma proteins ("finger, " "epidermal growt