Tissue-type plasminogen activator: Intracoronary applications
โ Scribed by Tiefenbrunn, Alan J.
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 919 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0098-6569
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Defibrotide, a polydeoxyribonucleotide of mammalian origin, has been shown to reduce the blood level of the plasminogen activator inhibitor, and so to increase the activity of tissue plasminogen activator without any adverse effect. A randomized, double-blind, placebo-controlled study has been done
To investigate the effect of tissue-type plasminogen activator (t-PA) on blood coagulation, we examined the effects of the addition of t-PA to normal pool plasma (NPP) on clotting times such as diluted prothrombin time (PT) and kaolin clotting time (KCT). The diluted PT but not the KCT was significa