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Tissue-specificity of the nonhistone protein that inhibits RNA synthesis in vitro

✍ Scribed by Nina C. Kostraba; Ruey M. Loor; Tung Y. Wang

Book ID
118311334
Publisher
Elsevier Science
Year
1977
Tongue
English
Weight
571 KB
Volume
79
Category
Article
ISSN
0006-291X

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## Abstract __SELEX was used to create an RNA aptamer targeted to protein tyrosine phosphatase 1B (PTP1B), an enzyme implicated in type 2 diabetes, breast cancer and obesity. We found an aptamer that strongly inhibits PTP1B in vitro with a__ K__~i~ of less than 600 pM. This slow‐binding, high‐affin