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Tissue specificity of chromosomal rearrangements in ataxia-telangiectasia

โœ Scribed by T. L. Kojis; R. R. Schreck; R. A. Gatti; R. S. Sparkes

Publisher
Springer
Year
1989
Tongue
English
Weight
1007 KB
Volume
83
Category
Article
ISSN
0340-6717

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Ataxia-telangiectasia (A-T) is an autosomal recessive disease involving chromosomal instability, susceptibility to cancer and X-ray hypersensitivity. The latter two features are expressed to a limited extent in the heterozygous carriers of A-T mutations. Although fibroblast lines from A-T heterozygo