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Tissue-specific signatures of activating PIK3CA and RAS mutations in carcinosarcomas of gynecologic origin

✍ Scribed by Whitfield B. Growdon; Breton N. Roussel; Vanessa L. Scialabba; Rosemary Foster; Dora Dias-Santagata; A. John Iafrate; Leif W. Ellisen; Rosemary H. Tambouret; Bo R. Rueda; Darrell R. Borger


Book ID
113962714
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
433 KB
Volume
121
Category
Article
ISSN
0090-8258

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## Abstract Transplacental carcinogenesis represents a good model in which to study the involvement of tissue‐specific oncogene activation in carcinogenesis because a single exposure to a carcinogen induces tumors at various sites. We tested tumors of the skin, liver, and lung produced in mice afte