Tissue Restricted Gene Expression Assayed by Direct DNA Injection into Cardiac and Skeletal Muscle

Disposition and gene expression characte

Disposition and gene expression characteristics in solid tumors and skeletal muscle after direct injection of naked plasmid DNA in mice

✍ Atsushi Kawase; Takehiko Nomura; Kei Yasuda; Naoki Kobayashi; Mitsuru Hashida; Y 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 339 KB

Previous studies have suggested that direct injection of naked plasmid DNA (pDNA) into solid tumors can be a useful method for in vivo gene transfer into tumor cells. To gain more insight into this approach, we studied the disposition and gene expression characteristics of naked pDNA after intratumo