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Tissue reactions induced by modified poly(vinyl alcohol) hydrogels in rabbit cornea

✍ Scribed by Kobayashi, Hisatoshi ;Ikada, Yoshito ;Moritera, Takeshi ;Ogura, Yuichiro ;Honda, Yoshihito

Book ID
102873178
Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
704 KB
Volume
26
Category
Article
ISSN
0021-9304

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✦ Synopsis

The purpose of this study was to compare the tissue reactions induced by modified poly(viny1 alcohol) (PVA) hydrogels with other materials implanted in the rabbit cornea. PVA hydrogels with and without covalently bonded collagen were compared to ethylene-vinyl alcohol copolymer, and polysulfone discs. These materials were implanted in the rabbit corneal stroma. The resultant tissue reactions were histologically and clinically studied. The PVA hydrogels had high flux rates of glucose and L-lactic acid in vitro. Covalent immobilization of collagen onto their surface was found to render them more biocompatible. However, excessive ulceration and vascularization of the cornea still ocurred in uivo, possibly because of extremely little blinking of the rabbits, which might cause desiccation of the cornea. 0 1992 John Wiley & Sons, Inc.

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