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Tissue-plasminogen activator-induced ischemic brain injury is reversed by melatonin: role of iNOS and Akt

✍ Scribed by Ertugrul Kilic; Ülkan Kilic; Russel J. Reiter; Claudio L. Bassetti; Dirk M. Hermann

Book ID
111264235
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
152 KB
Volume
39
Category
Article
ISSN
0742-3098

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## Abstract Recombinant tissue plasminogen activator (rt‐PA) treatment improves functional outcome after acute ischemic stroke, inducing reperfusion by its thrombolytic activity. Conversely, there is evidence that rt‐PA can mediate neuronal damage after ischemic brain injury in vivo. In addition to