Tissue lipid peroxidation and glutathione-dependent enzyme status in patients with oral squamous cell carcinoma
✍ Scribed by M. Saroja; S. Balasenthil; S. Nagini
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 78 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0263-6484
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✦ Synopsis
We examined the extent of lipid peroxidation and the status of reduced glutathione (GSH) and the GSH-dependent enzymes Ð glutathione peroxidase (GPx) and glutathione-S-transferase (GST) Ð in oral tumour tissues from 33 adult oral cancer patients and an equal number of age-and sex-matched normal subjects. Diminished lipid peroxidation in the oral tumour tissue was accompanied by a signi®cant decrease in phospholipids and an increase in the cholesterol/phospholipid (C/P) ratio. The concentration of glutathione and the activities of GPx and GST were elevated in oral tumour tissues. These ®ndings suggest that GSH-and GSH-dependent enzymes play a crucial role in tobacco-related tumourigenesis and may be considered as markers of carcinogen exposure.