Tissue Engineering Strategies Designed to Realize the Endogenous Regenerative Potential of Peripheral Nerves
✍ Scribed by Vivek Mukhatyar; Lohitash Karumbaiah; Julie Yeh; Ravi Bellamkonda
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 372 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0935-9648
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
http://doi.wiley.com/10.1002/adma.v21:32/33
Bridging peripheral nerve gaps without the use of autografts has significant clinical importance. But in order to rationally design novel scaffolds, a good understanding of the nerve regeneration process is vital. Appropriate amount of structural and chemical cues are required to stimulate the endogenous mechanisms of repair and functional recovery. Synthetic and natural materials present various opportunities to induce the growth of supporting cells as well as promote axon regeneration. An overview of tissue engineering strategies currently being explored that stimulate the different steps of the regenerative sequence is presented.