Tissue Engineering in Regenerative Medicine

✍ Scribed by Andrew D. Leavitt (auth.), Harold S. Bernstein (eds.)

• Publisher: Humana Press
• Year: 2011
• Tongue: English
• Leaves: 441
• Series: Stem Cell Biology and Regenerative Medicine
• Edition: 1
• Category: Library

✦ Synopsis

Over the past decade, significant advances in the fields of stem cell biology, bioengineering, and animal models have converged on the discipline of regenerative medicine. This volume provides a state-of-the-art report on tissue engineering toward the goals of tissue and organ restoration and regeneration. Examples from different organ systems are used to illustrate progress with growth factors to assist in tissue remodeling; the capacity of stem cells for restoring damaged tissues; novel synthetic biomaterials to facilitate cell therapy; transplantable tissue patches that preserve three-dimensional structure; synthetic organs generated in culture; aspects of the immune response to transplanted cells and materials; and the development of suitable animal models for non-human clinical trials. Throughout the chapters, the reader will observe a common theme of basic discovery informing clinical translation, and clinical studies in animals and humans guiding subsequent experiments at the bench.

✦ Table of Contents

Front Matter....Pages i-xiv
Front Matter....Pages 1-1
Hematopoietic Stem Cell Transplantation: Reflections on Yesterday and Thoughts for Tomorrow....Pages 3-16
Human Embryonic Stem Cells in Regenerative Medicine....Pages 17-38
Current Status of Induced Pluripotent Stem Cells....Pages 39-52
Mesenchymal Stromal Cells: Latest Advances....Pages 53-74
Front Matter....Pages 75-75
The Role of Mechanical Forces in Guiding Tissue Differentiation....Pages 77-97
Synthetic Multi-level Matrices for Bone Regeneration....Pages 99-122
Directing Cell Fate Through Biomaterial Microenvironments....Pages 123-140
Front Matter....Pages 141-141
Basic Considerations with Cell Sheets....Pages 143-159
Myocardial Repair and Restoration....Pages 161-196
Skeletal Muscle Engineering: The Need for a Suitable Niche....Pages 197-209
Restoring Blood Vessels....Pages 211-220
Engineering Functional Bone Grafts....Pages 221-235
Engineering Functional Cartilage Grafts....Pages 237-250
Adult Stem Cells and Regeneration of Adipose Tissue....Pages 251-269
Front Matter....Pages 271-271
Hollow Organ Engineering....Pages 273-295
Engineering Complex Synthetic Organs....Pages 297-313
Liver Regeneration and Tissue Engineering....Pages 315-332
Front Matter....Pages 333-333
Immune Modulation for Stem Cell Therapy....Pages 335-352
Regenerative Medicine and the Foreign Body Response....Pages 353-375
Front Matter....Pages 377-377
Small Animal Models of Tissue Regeneration....Pages 379-391
Front Matter....Pages 377-377
Use of Large Animal and Nonhuman Primate Models for Cell Therapy and Tissue Engineering....Pages 393-413
Back Matter....Pages 415-426

✦ Subjects

Stem Cells; Cell Biology; Biotechnology