Tissue edema does not change gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA)-enhanced T1 relaxation times of viable myocardium
✍ Scribed by Gang Li; Bo Xiang; Guangping Dai; Anthony Shaw; Hongyu Liu; Baofeng Yang; Mike Jackson; Roxanne Deslauriers; Ganghong Tian
- Book ID
- 102375061
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 363 KB
- Volume
- 21
- Category
- Article
- ISSN
- 1053-1807
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✦ Synopsis
Abstract
Purpose
To determine whether tissue edema changes gadolinium‐diethylenetriamine pentaacetic acid (Gd‐DTPA)‐enhanced T~1~ relaxation times of the viable myocardium.
Materials and Methods
A total of 16 isolated pig hearts were divided into four groups (N = 4/group) and perfused in a Langendorff apparatus. Gd‐DTPA was injected into the aortic perfusion line. Tissue edema was then induced by two hours of simultaneous arterial/venous perfusion (SAVP). Myocardial water content and T~1~ relaxation times were monitored throughout SAVP. The volumes of the extracellular and intracellular compartments were assessed using ^31^P MRS‐detectable markers, phenylphosphonic acid (PPA) and dimethyl methylphosphonate (DMMP).
Results
Tissue water content in both viable and infarcted myocardium increased significantly during two‐hour SAVP. However, Gd‐DTPA‐enhanced T~1~ relaxation times of the viable myocardium remained relatively unchanged. Infarcted myocardium, on the other hand, exhibited significant T~1~ shortening during SAVP. Furthermore, SAVP resulted in significant expansions of both extracellular and intracellular compartments, but the ratio of the volumes of the two compartments remained relatively constant.
Conclusion
Tissue edema in the viable myocardium does not increase the relative distribution volume of the contrast agent. As a result, edema does not change Gd‐DTPA‐enhanced T~1~ relaxation times of the viable myocardium. J. Magn. Reson. Imaging 2005;21:744–751. Published 2005 Wiley‐Liss, Inc.