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Tissue distribution of murine hemopoietic growth factor mRNA production

✍ Scribed by Anthony B. Troutt; Frank Lee

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
762 KB
Volume
138
Category
Article
ISSN
0021-9541

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✦ Synopsis

We have studied the tissue distribution of interleukin (IL) and hemopoietic colony-stimulating factor (CSF) transcripts in mice by S1 -nuclease protection analysis. Accumulation of several of these mRNAs in response to intravenous injection of lipopolysaccharide (LPS) appears to occur in a tissue-specific fashion. IL-1 a transcripts accumulate in spleen and lung; IL-6 transcripts accumulate in kidney, heart, and spleen; granulocyte-macrophage-CSF transcripts accumulate in lung and heart; and granulocyte-CSF transcripts accumulate in heart. Three distinct patterns of in vivo mRNA accumulation were detected: 1) silentinterleukins 2-5 showed no transcripts in either LPS-treated or untreated animals;

  1. induced-IL-1 a, IL-6, granulocyte-macrophage (GM)-CSF, and G-CSF transcripts were increased in abundance in LPS-injected mice; and 3 ) constitutive-M-CSF transcripts were found in similar amounts in both untreated and treated mice and were present in all tissues examined.

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