Hexachlorobiphenyls 149 (2,2,3,4,5,2,4,4,5, are among the more abundant congeners in many heavy chlorobiphenyl industrial mixtures. The former appears to be one of the most readily degradable congeners in several biotic matrices. In this paper experimental clues suggesting that the ratio of the two
Tissue Distribution of Methylsulfonyl Metabolites Derived from 2,2′,4,5,5′-Penta- and 2,2′,3,4′,5′,6-Hexachlorobiphenyls in Rats
✍ Scribed by K. Haraguchi; Y. Kato; R. Kimura; Y. Masuda
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 240 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0090-4341
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Key words: 2,2'.4.4',5,5'-hexachlorobiphenyl; rat; subchronic toxicity. The subchronic toxicity of 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) was investigated in rats after 13 weeks of dietary exposure. Groups of 10 male and 10 female rats were administered PCB 153 in their diet at levels of 0.05,
The tissue distribution, metabolism and excretion of 14C-2,2',4,4',5-pentachlorodiphenyl ether (PCDE) were studied in the rat. Radioactivity was distributed in all tissues examined, with the highest concentrations being found in the fat followed by the skin, liver, kidney and muscle. Most of the rad