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Tissue distribution of absorbed humic acids

✍ Scribed by Tien-Shang Huang; Fung-Jou Lu; Chang-Wu Tsai

Publisher
Springer Netherlands
Year
1995
Tongue
English
Weight
365 KB
Volume
17
Category
Article
ISSN
1573-2983

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✦ Synopsis

Distribution of humic acids (HA) in rats was studied using radioiodinated HA injected intraperitoneally. Distribution of 1251 was also studied for comparison. The distribution pattern of HA differed greatly from that of 1251. Except in the thyroid and skin, 1251 was excreted from the body within 24 hours, whereas a large proportion of HA remained in the liver, kidney, skin, thyroid, bone and muscle. The difference in the distribution pattern and organ/serum radioactivity ratio suggests different kinetics for 1251 and 1251-HA. The distribution pattern of HA Correlated very well with the increased prevalences of organ diseases in the blackfoot disease endemic area, as reflected:in epidemiologic studies. It is hypothesised that HA-metal complexes are possible etiological factors of diseases such as goitre, hepatoma, bladder cancer, vascular disease and diabetes mellitus, and that free radicals are the common causative factor.

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