✦ LIBER ✦
Tissue culture cytotoxicity assay for cyclophosphamide metabolites in rat body fluids
✍ Scribed by Fred A. Weaver; Anthony R. Torkelson; Walter A. Zygmunt; Henry P. Browder
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- English
- Weight
- 464 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
✦ Synopsis
An in vitro cytotoxicity assay for cyclophosphamide metabolites in rat body fluids is described. Of the two tissue culture tumor cell lines employed, the Walker-256 rat carcinosarcoma was more sensitive to metabolite levels than the L-1210 mouse lymphocytic leukemia. The Walker-256 system detected cyclophosphamide metabolite levels two orders of magnitude lower than the commonly used 4-(p-nitrobenzyl)pyridine analytical procedure.