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Tissue Concentrations of Clozapine and its Metabolites in the Rat

✍ Scribed by Baldessarini, Ross J.; Centorrino, Franca; Flood, James G.; Volpicelli, Sheila A.; Huston-Lyons, David; Cohen, Bruce M.


Book ID
123616740
Publisher
Nature Publishing Group
Year
1993
Tongue
English
Weight
636 KB
Volume
9
Category
Article
ISSN
1470-634X

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Pooled plasma from healthy volunteers was spiked with pure, synthetic clozapine or clozapine N-oxide and then made alkaline with either sodium hydroxide or sodium carbonate. The alkalized samples were allowed to stand at room temperature for various time intervals before extraction with organic solv